Billy Connolly's Route 66 is a British documentary television series presented by Billy Connolly. It focused on his travels along the famous United States highway Route 66. The series, which consisted of four episodes, was shown on the British television network ITV. The first episode aired at 9pm on 15 September 2011.

Connolly's journey along Route 66 began in Chicago, Illinois, (the start of Route 66) and reached St. Louis, Missouri, as an initial destination. The show featured the Willis Tower (the tallest building in the United States) as a lead-in to Connolly's meeting with an Illinois champion pie-maker, an Amish family and two female St. Louis residents whose homes were destroyed by a tornado.

Started where the first one finished - in St. Louis, with Connolly climbing the Gateway Arch. Now in the American West, Connolly visited a wolf sanctuary, participated in a Civil War re-enactment, hunted for turkey, sat in the world's largest rocking chair and visited a memorial commemorating the victims of the 1995 Oklahoma City bombing, in which 168 people lost their lives in the Alfred P. Murrah Federal Building.

Connolly joined a cattle drive in Oklahoma City, before he moved onward to Texas to visit the ghost town of Glenrio and the Devil's Rope Museum. He later met two men who helped to create the atomic bomb in Los Alamos, New Mexico before taking part in a rodeo in Arizona.

Connolly visited a massive meteorite crater as well as the Grand Canyon in Arizona. He took the viewers into a sanctuary for unwanted exotic pets, where he fed a lion cub and met with a campaigner who was trying to keep the historic Route 66 alive. Connolly's journey concluded at the end of Route 66 in Santa Monica.